ERCC1 , RRM1



References:
http://www.jnccn.org/content/8/7/740.extract

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0003695one.0003695


Pathology of lung adenocarcinoma

grade 1: nonmucinous lepidic
grade 2: acinar, papillary
grade 3: solid, micropapillary

Nonmucinous BAC: more EGFR
Mucinous BAC: more K-ras
建議所有的adenocarcinoma 或 NSCLC NOS 都要測 EGFR

References:

1. http://www.cscpweb.org/Travis_Lung%20Ade.pdf

2. International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Classification of Lung Adenocarcinoma JTO 2011
http://journals.lww.com/jto/Fulltext/2011/02000/International_Association_for_the_Study_of_Lung.4.aspx





Immunohistochemical staining in lung cancer

Malignant mesothelioma: WT-1, calretinin, D2-40, cytokeratin 5/6 (+)
CEA, B72.3, Ber-EP4, MOC31 (-)
Solitary fibrous tumor: vimentin, CD34 (+), keratin (-)
Small cell lung cancer: immunoreactive for keratin, epithelial membrane antigen, TTF-1 (+)

Primary lung adenocarcinoma: TTF-1 (+), CK7 (+), CK20 (-)
Metastatic adenocarcinoma from colon: CDX-2 (+), CK7(-), CK20(+)

SCC: CK5/6 (+), p63 (+), 34βE12 (+)


DNA mutation in lung cancer
small cell lung cancer 2nd line C/T: topotecan (not irinotecan)

K-ras: chromosome 12


Tumor suppressor gene: 3p21.3 (site of RASSF1A), 3p14.2 (FHIT), 9p21 (p16), and 17p13 (p53).

KRAS Mutations in Non–Small Cell Lung Cancer

http://pats.atsjournals.org/cgi/content/abstract/6/2/201

EGFR: never smoker 多, survival 較好
KRAS : tobacco exposure, uncommon in SCC
VEGF: poor prognosis

Angiogenesis in non-small cell lung cancer: The prognostic impact of neoangiogenesis and the cytokines VEGF and bFGF in tumours and blood

http://www.lungcancerjournal.info/article/S0169-5002%2805%2900498-8/abstract

Oncogenes and Antioncogenes in Lung Tumorigenesis

http://chestjournal.chestpubs.org/content/109/5_Supplement/130S.abstract

NIPPV indication:
acute exacerbation of COPD
cardiogenic pulmonary edema
immunocompromised
soon after extubation


Clinical review: Critical illness polyneuropathy and myopathyhttp://ccforum.com/content/12/6/238

reduction in or absence of deep tendon reflexes
serum creatine kinase, 並非很有幫忙
Risk factor: renal failure, renal replacement therapy, hyperglycemia
Biopsy result: a. diffuse non-necrotising 'cachectic' myopathy b. myopathy with selective loss of thick (myosin) filaments c. acute necrotising myopathy